Home
Up
Contacts
Blood Disorders
Chemotherapy
Transplantation
Blood Products
Bone Marrow
Links
PVT

Perth Haematology :: Dr Steven Ward

Acute Lymphoblastic Leukaemia (ALL)

 

 

Acute Lymphoblastic Leukaemia (ALL) is a highly malignant cancer of the marrow and blood cells of lymphoid origin.

 

ALL Classification

Classification can be done by a number of methods.

Traditionally ALL is divided into L1, L2 and L3 based on the cell morphology.

More modern classification relies on the immunophenotype, or cytogenetic/molecular abnormalities:

 

ALL is divided by the cell of origin and maturity of that cell:

B-lineage ALL: Pro-B, pre-B, Mature B-cell - account for 80%

T-cell ALL: early T, thymic T, mature T - account for 10-15%

 

 

Antigen Expression during B-cell Development

NORMAL Pro-B Pre pre B Pre B immature B mature B Activated B Plasma Cell
TdT      
IgR              
mu (IgM)            
Kappa          
Lambda
 
       
Surface Ag              
HLA-DR            
CD19          
CD20
 
       
CD10      
CD38
 
sIg      
DISEASE pre pre B ALL pre-B ALL CLL, B-cell lymphoma Myeloma

 

Diagnosis of ALL (pdf)

 

Therapy for ALL

 

 

 

ALL Therapy (pdf)