Perth Haematology :: Dr Steven Ward
Acute Lymphoblastic Leukaemia (ALL)
Acute Lymphoblastic Leukaemia (ALL) is a highly malignant cancer of the marrow and blood cells of lymphoid origin.
Classification can be done by a number of methods.
Traditionally ALL is divided into L1, L2 and L3 based on the cell morphology.
More modern classification relies on the immunophenotype, or cytogenetic/molecular abnormalities:
ALL is divided by the cell of origin and maturity of that cell:
B-lineage ALL: Pro-B, pre-B, Mature B-cell - account for 80%
T-cell ALL: early T, thymic T, mature T - account for 10-15%
Antigen Expression during B-cell Development
Therapy for ALL