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Perth Haematology :: Dr Steven Ward

Chronic MyeloMonocytic Leukaemia (CMML)

 

CMML is now classified as a cross-over Myelodysplastic / Myeloproliferative disorder (MDS/MPD), as it shares features of both groups of disorders.

 

 

The Myelodysplastic features of CMML include:

The Myeloproliferative features of CMML include:

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Anaemia

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Low white cell count (neutropenia)

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Thrombocytopenia

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Abnormal bruising and bleeding

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Monocytosis

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High white cell count (neutrophils, monocytes, monocyte precursors and blasts)

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Splenomegaly

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Tissue infiltration by monocytic cells

Treatment Treatment:
bulletSupportive
bulletTransfusion
bulletTreatment of infection
bulletReducing proliferative features (high WCC or splenomegaly)
bullethydroxyurea or etoposide
bulletMay exacerbate the dysplasia and lower Hb, platelets, neutrophils

 

CMML may go on to develop:

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features of one of the myeloproliferative disorders
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eg: myelofibrosis [link to MPD]

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secondary acute leukaemia  (AML) [link to AML]