Perth Haematology :: Dr Steven Ward
Myelodysplasia (or MyeloDysplastic Syndrome [MDS]) is a group of blood disorders characterised by low cell counts in the blood due to the inability of the marrow to produce normal fully-mature cells. The cells affected can be white cells, red cells, platelets, or any combination. The cells are not allowed to mature properly in the marrow and often do not contain all the necessary ingredients to allow them to function properly. The cells therefore look funny and may not do their job properly (hence the term dysplasia). The cells are often removed from the circulation earlier than usual. the marrow is often very active in producing cells, but the circulating cell counts are low. Sometimes increased numbers of precursor cells are seen in the blood.
Prognostic Score for MDS (IPSS)
Cytogenetics: Good: normal, -Y, del(5q), del(20q) Cytopenia: Neutrophils: <1.8 x 109/L
Poor: complex (>=3 abn), chrom 7 abn Hb < 100 g/L
Intermediate: others Platelets: <100 x 109/L